Oorun ti o ni ibatan si wahala ati awọn rudurudu iranti jẹ iṣoro ilera pataki ti o dojukọ ọpọlọpọ eniyan. Awọn homonu itusilẹ corticotropin (CRH) ninu awọn sẹẹli paraventricular (PVN) ninu hypothalamus ṣe ipa pataki ninu igbega ti awọn ipele cortisol ni idahun si wahala sibẹsibẹ ọna neuronal jẹ aimọ. Ninu iwadi kan laipẹ lori awọn eku yàrá, awọn oniwadi rii pe iwuri ti awọn neuronu homonu ti o tu silẹ corticotropin ni arin paraventricular ti hypothalamus (CRH).PVN) tun ṣe agbejade oorun idalọwọduro ati iranti ailagbara, iru si awọn ipa ti a ṣe nipasẹ aapọn ihamọ, bii, mejeeji aapọn ati iwuri ti CRHPVN Awọn neuron ṣe agbejade awọn ipa buburu kanna lori oorun ati iranti. Ni idakeji, awọn ipa lori oorun ati iranti jẹ idakeji, ie, oorun ati iranti dara si nigbati CRHPVN Awọn neuronu ti dina. Awọn awari daba pe awọn ipa buburu ti aapọn lori oorun ati iranti jẹ ilana nipasẹ CRHPVN awọn ọna neuronal. Niwon idilọwọ CRHPVN awọn neurons lakoko aapọn ṣe ilọsiwaju oorun ati awọn iṣẹ iranti, ifọkansi CRHPVN Awọn ipa ọna neuronal le jẹ ilana ti o dara fun itọju oorun ti o ni ibatan si wahala ati awọn rudurudu iranti.
wahala jẹ ipo aibalẹ ati aibalẹ ti o ṣẹlẹ nipasẹ awọn ipo ti o nira ni igbesi aye. O jẹ idahun ti ara ti o fa wa lati koju awọn ọran ati awọn irokeke niwaju wa. Gbogbo eniyan ni iriri wahala ni aaye kan ninu igbesi aye. O kan ilera ati alafia wa ti a ko ba ṣakoso ati farada daradara. Ọkan ninu awọn ipa bọtini ti aapọn ni awọn idalọwọduro oorun ati awọn rudurudu ti iranti.
Ara wa ṣe idahun si aapọn nipasẹ iṣelọpọ cortisol, “homonu wahala.” Ni awọn ipo aapọn, hypothalamus ṣe aṣiri homonu ti o tu silẹ corticotropin (CRH) eyiti o mu ki ẹṣẹ pituitary ṣiṣẹ pọ si corticotropin tabi homonu adrenocorticotropic (ACTH), gẹgẹ bi apakan ti hypothalamic-pituitary-adrenal. agbe (apa HPA). Awọn corticotropin stimulates adrenal kotesi lati kopọ ati ki o tu corticosteroids, o kun glucocorticoids. Ipele cortisol ti o ga yori si idalọwọduro ilana oorun ati aberrations ni rhythm circadian nitorinaa iṣẹlẹ ti awọn rudurudu oorun ti o ni ibatan si wahala. Hypothalamus ṣe ipa pataki ninu eyi, ni pataki awọn homonu itusilẹ corticotropin (CRH) awọn iṣan inu arin paraventricular (PVN) ninu hypothalamus. Sibẹsibẹ, awọn ipa ọna ti bi aapọn ṣe fa oorun ati awọn rudurudu iranti jẹ koyewa. Iwadi laipe kan ti wo eyi.
Lati ṣe iwadii bawo ni homonu ti o tu silẹ corticotropin (CRH) awọn neurons ti o wa ni ipilẹ paraventricular (PVN) ninu hypothalamus ni ibatan pẹlu oorun ti o ni ibatan si aapọn ati awọn rudurudu iranti, awọn oniwadi fa aapọn ninu awọn eku yàrá nipa didi wọn sinu tube ṣiṣu kan. Awọn eku ti wahala ni a rii pe wọn ni idamu oorun. Wọn tun tiraka pẹlu iranti aye nigba idanwo ni ọjọ keji. Awọn ipa wọnyi ti aapọn lori oorun ati iranti ninu awọn eku yàrá wa lori awọn laini ti a nireti. Awọn oniwadi lẹhinna ṣawari ti iwuri ti corticotropin-itusilẹ homonu ti o nyọ awọn neuronu ni arin paraventricular (CRH).PVN) ti hypothalamus ṣe awọn ipa kanna lori oorun ati iranti ni awọn eku yàrá ti a ko ni wahala.
O yanilenu, imuṣiṣẹ ti awọn neuronu homonu ti o tu silẹ corticotropin ni arin paraventricular ti hypothalamus (CRH)PVN) tun ṣe agbejade oorun idalọwọduro ati iranti ailagbara, iru si awọn ipa ti a ṣe nipasẹ aapọn ihamọ, bii, mejeeji aapọn ati iwuri ti CRHPVN Awọn neuronu ṣe awọn ipa kanna lori oorun ati iranti. Ni idakeji, awọn ipa lori oorun ati iranti jẹ idakeji, ie, oorun ati iranti dara si nigbati CRHPVN Awọn neuronu ti dina.
Awọn abajade ti o wa loke daba pe awọn ipa buburu ti wahala lori oorun ati iranti jẹ ilana nipasẹ CRHPVN awọn ọna neuronal. Eyi ṣe pataki. Niwon idilọwọ CRHPVN awọn neurons lakoko aapọn ṣe ilọsiwaju oorun ati awọn iṣẹ iranti, itọju oorun ti o ni ibatan si aapọn ati awọn rudurudu iranti nipasẹ didi CRHPVN Awọn ipa ọna neuronal le ṣee ṣe ni ọjọ iwaju. Idagbasoke lọwọlọwọ jẹ igbesẹ kekere siwaju ni itọsọna yẹn.
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To jo:
- Wiest, A., et al 2025. Ipa ti awọn neuronu CRH hypothalamic ni iṣakoso ipa ti aapọn lori iranti ati oorun. Iwe akosile ti Neuroscience. Atejade 9 Okudu 2025. DOI: https://doi.org/10.1523/JNEUROSCI.2146-24.2025
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 neurons in the paraventricular nucleus (PVN) in the hypothalamus play a pivotal role in elevation of cortisol levels in response to stress however neuronal pathway is unknown. In a recent study on laboratory mice, researchers found that stimulation of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus (CRHPVN) also produced disrupted sleep and impaired memory, similar to effects produced by the restraint stress, viz., both stress and stimulation of CRHPVN neurons produced same adverse effects on sleep and memory. Conversely, effects on sleep and memory were opposite, i.e., sleep and memory improved when CRHPVN neurons were blocked. The findings suggest that the adverse effects of stress on sleep and memory are regulated by CRHPVN neuronal pathways. Since inhibiting CRHPVN neurons during stress improves sleep and memory functions, targeting CRHPVN neuronal pathways may be a good strategy for treatment of stress-related sleep and memory disorders.){kind=link}